| The Cancer Genome Atlas Research Network (Leaders: Chin L. and Meyerson M.) Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature, 2008. doi:10.1038 [pdf] |
| Kim MJ, Gans J, Nogueira CN, Wang A, Paik JH, Feng, B, Brennan C, Hahn W, Cordon-Cardo C, Wagner SN, Flotte T, Duncan L, Granter SR and Chin L. Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene. Cell, 2006. 125, 1269-1281. [pdf] |
| Chin L, Garraway LA and Fisher DE. Malignant melanoma: genetics and therapeutics in the genomic era. Genes & Development, 2006. 20: 2149 - 2182. [pdf] |
| 0Bosenberg, M., Muthusamy, V., Curley, D. P., Wang, Z., Hobbs, C., Nelson, B., Nogueira, C., Horner, J. W., 2nd, Depinho, R., and Chin, L.. Characterization of melanocyte-specific inducible Cre recombinase transgenic mice. Genesis, 2006. 44, 262-267. |
| Carrasco DR, Tonon G, Huang Y, Zhang Y, Sinha R, Feng B, Stewart JP, Zhan F, Khatry D, Protopopova M, Protopopov A, Sukhdeo K, Hanamura I, Stephens O, Barlogie B, Anderson KC, Chin L, Shaughnessy JD Jr, Brennan C, Depinho RA. High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients. Cancer Cell. 2006 Apr;9(4):313-25. [pdf] [Data] |
| Bardeesy N, Aguirre AJ, Chu GC, Cheng KH, Lopez LV, Hezel AF, Feng B, Brennan C, Weissleder R, Mahmood U, Hanahan D, Redston MS, Chin L and DePinho RA. Both p16Ink4a and the p19ARF-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. PNAS 2006. 103(15): 947-52.[pdf] |
| Muthusamy V, Hobbs C, Nogueira C, Cordon-Cardo C, McKee P, Chin L, Bosenberg MW. Amplification of CDK4 and MDM2 in Malignant Melanoma. Genes Chromosomes and Cancer, 2006. 45, 447-454. |
| Tang Y, Kim MJ, Carrasco D, Kung AL, Chin L and Weissleder R.In vivo assessment of RAS-dependent maintenance of tumor angiogenesis by real-time MRI. Cancer Research 2005, 65(18):8324-30. [pdf] |
| Tonon G, Wong KK, Maulik G, Brennan C, Feng B, Zhang Y, Khatry DB, Protopopov A, You MJ, Aguirre AJ, Martin ES, Yang Z, Ji H, Chin L, DePinho RA. High resolution genomic profiles of human lung cancer. PNAS 2005, 102(27): 9625-9630 [pdf] [Data] |
| Westbrook TF, Martin ES, Schlabach MR, Leng Y, Liang AC, Feng B, Zhao JJ, Roberts TM, Mandel G, Hannon GJ, DePinho RA, Chin L, Elledge SJ. A genetic screen for candidate tumor suppressors identifies REST. Cell, 2005. 121:1-12. [pdf] |
| Bardeesy N, Kim MJ, Xu J, Kim RS, Shen Q, Bosenberg MW, Wong WH, Chin L. The role of EGFR signaling in RAS-driven melanoma. Mol Cell Biol, 2005, 25(10):4176-4188. [pdf] |
| Wang G, Mahr E, Brennan C, Leo C, Chin L, Kaur M, Zhu P, Rook M, Wolfe JL, Makrigiorgos GM. DNA amplification method tolerant to sample degradation. Genome Research, 2004. 14:2357-2366. |
| Blelloch RH, Hochedlinger K, Yamada Y, Brennan C, Kim M, Mintz B, Chin L, Jaenisch R. Nuclear cloning of embryonal carcinoma cells. PNAS 2004,101(39):13985-90. |
| Hochedlinger K, Blelloch R, Brennan CW, Yamada Y, Kim MJ, Chin L, and Jaenisch R. Reprogramming of a melanoma genome by nuclear transplantation. Genes Dev. 2004, 18(15):1875-85. [pdf] |
| Brennan CW, Zhang, Y, Leo C, Feng C, Cauwels C, Aguirre AJ, Kim MJ, Protopopov A and Chin L. High-resolution global profiling of genomic alterations with long oligonucleotide microarray. Cancer Research 2004, 64(14):4744-8. [ pdf] [Data] |
| Aguirre A, Brennan C, Bailey G, Sinha R, Feng B, Leo C, Zhang Y, Zhang, J., Gans, J.D., Bardeesy N, Cauwels C, Cordon-Cardo C, Redston M, DePinho RA and Chin L. High-resolution characterization of the pancreatic adenocarcinoma genome. PNAS 2004, 101(24):9067-72. [pdf] [Data] |
| Wang G, Brennan C, Rook M, Wolfe JL, Leo C, Chin L, Pan H, Liu WH, Price B, Makrigiorgos GM. Balanced-PCR amplification allows unbiased identification of genomic copy changes in minute cell and tissue samples. Nucleic Acids Res. 2004 May 21;32(9):76. |
| O'Hagan RC, Brennan CW, Strahs A, Zhang X, Kannan K, Donovan M, Cauwels C, Sharpless NE, Wong WH, and Chin L. Array CGH for tumor classification and gene discovery in mouse models of malignant melanoma. Cancer Research 2003, 63(17):5352-6. [pdf] |
| Sharpless NE, Kannan K, Xu J, Bosenberg M and Chin, L. Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo. Oncogene 2003, 22(32):5055-9. [pdf] |
| Kannan K, Sharpless NE, Xu J, O'Hagan RC, Bosenberg M, and Chin L. Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model. Proc Nat Acad Sci USA, 2003, 100(3):1221-5.[pdf] |
| O'Hagan RC, Chang S, Maser RS, Mohan R, Artandi SE, Chin L, and DePinho RA. Telomere dysfunction provikes regional amplification and deletion in cancer genomes. Cancer Cell 2002. 2:149-155. [pdf] |
| Porter D, Lahti-Domenici J, Torres-Arzayus M, Chin L, Polyak K. Expression of high in normal-1 (HIN-1) and uteroglobin related protein-1 (UGRP-1) in adult and developing tissues. Mech Dev. 2002 Jun;114(1-2):201-4. |
| You MJ, Castrillon DH, Bastian, BC, O'Hagan RC, Bosenberg MW, Parsons R, Chin L, DePinho RA. Functional collaboration between PTEN and INK4a tumor suppressors in tumorigenesis. Proc Nat Acad Sci USA 2002; 99:1455-60.[pdf] |
| Sharpless NE, Ferguson DO, O'Hagan RC, Castrillon DH, Lee C, Farazi PA, Alson S, Fleming J, Morton CC, Frank K, Chin L, Alt FW, DePinho RA. Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions. Mol Cell 2001;6:1187-96. [pdf] |
| Yang J, Luan J, Yu Y, Li C, DePinho RA, Chin L, Richmond A. Induction of melanoma in murine macrophage inflammatory protein 2 transgenic mice heterozygous for inhibitor of kinase/alternate reading frame. Cancer Res. 2001 Nov 15;61(22):8150-7. [pdf] |
| Hemann MT, Rudolph KL, Strong MA, DePinho RA, Chin L, Greider CW. Telomere dysfunction triggers developmentally regulated germ cell apoptosis. Mol Cell Biol, 2001. 12(7):2023-30. [pdf] |
| Wong AK, Alfert M, Castrillon DH, Shen Q, Holash J, Yancopoulos GD, Chin L. Excessive tumor-elaborated VEGF and its neutralization define a lethal paraneoplastic syndrome. Proc Nat Acad Sci USA, 2001; 98(13):7481-86.[pdf] |
| Bardeesy N, Bastian BC, Hezel A, Pinkel D, DePinho RA and Chin L. Dual inactivation of RB and p53 pathways in RAS-induced melanomas. Mol Cell Biol, 2001. 21(6):2144-2153. [pdf] |
| Artandi SE, Chang S, Lee S-L, Alson S, Gottlieb GJ, Chin L, and DePinho RA. Telomere dysfunction promotes non-reciprocal translocations and development of epithelial cancers in mice. Nature, 2000. 406(6796): 641-645. [pdf] |
| Chin L, Tam A, Pomerantz J, Wong M, Holash J, Bardeesy N, Shen Q, O'Hagan R, Pantginis J, Zhou H, Horner JW, Cordon-Cardo C, Yancopoulos GD, DePinho RA. Essential role for oncogenic RAS in tumor maintenance. Nature, 1999. 400: 468-472 |
| Chin L, Artandi SE, Shen Q, Tam A, Lee S-L, Gottlieb GJ, Greider CW and DePinho RA. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell, 1999. 97:527-538. [pdf] |
| Greenberg R, Chin L, Femino A, Gottlieb GJ, Singer R, Greider CW, DePinho, RA. Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aD2/3 Cancer-Prone Mouse. Cell, 1999. 97:515-526. [pdf] |
| Chin L, Pomerantz J, Polsky D, Jacobson M, Cohen C, Cordon-Cardo C, Horner JW, DePinho RA. Cooperative effects of INK4a and ras in melanoma susceptibility in vivo. Genes Devel 1997; 11(21): 2822-34.[pdf] |
| Schreiber-Agus N, Chin L, Chen K, Torres R, Rao G, Guida P, Skoultchi AI, DePinho RA.An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3. Cell 1995; 80(5):777-86. |
| Chin L, Schreiber-Agus N, Pellicer I, Chen K, Lee HW, Dudast M, Cordon-Cardo C, DePinho RA. Contrasting roles for Myc and Mad proteins in cellular growth and differentiation. Proc Natl Acad Sci USA 1995; 92(18):8488-92.[pdf] |
| Kabbarah O, and Chin L. Revealing the genomic heterogeneity of melanoma. Cancer Cell 2005. (6):439-41. |
| Kabbarah O, and Chin L. Advances in Malignant Melanoma: Genetic insights from Mouse and Man. Front Biosci. 2006; 11:928-42. |
| Chin, L. The genetics of malignant melanoma: lessons from mouse and human. Nature Review Cancer, 2003, 3(8):559-70. [pdf] |